Dr Ong graduated with honours from the University of Cambridge and pursued his cardiology specialist training in London “golden circuit” of heart centres at Hammersmith, Royal Brompton and Harefield Hospitals. He was appointed NHS cardiology consultant and Cathlab Director at the Lister Hospital and the Royal Brompton and Harefield NHS Trust in 2006. He was subsequently elected as Fellow of Royal College of Physicians and Fellow of the European Society of Cardiology in 2008.

After 23 years in England, Dr Ong moved to Singapore in 2009. From 2014 to Feb 2021, Dr Paul Ong was in the Interventional Cardiology Service at Tan Tock Seng Hospital. When he headed the department at TTSH, his team had transformed TTSH to become one of the best interventional cardiology centres in SE Asia.

Dr Ong is internationally renowned for his expertise in Primary Angioplasty to treat heart attack patients. He is the founder of the Asia Primary Angioplasty Congress (APAC) and the Asia Physiology and Coronary Imaging Course (APACi). He was also the Asia Champion of the Stent Save a Life initiative. These provided the ideal platform for specialists to exchange ideas and deliver better cardiac care in Asia.

Dr Ong is one of the few interventional cardiologists from Singapore to initiate his own multi-centre clinical trials studying hundreds of heart attack patients across Asia.  He was principal investigators of more than 20 large scale randomised clinical trials. He has over 60 high impact scientific publications in international medical journals. In recognition of his contribution in the field of interventional cardiology Dr Ong is regularly invited to sit in organising committee of scientific meetings and advisory boards.